Lung Cancer And Asbestos Exposure + Determining The Cause

For someone who works as a pipefitter, steam fitter, auto mechanic, boiler maker or works in the construction industry, or demolition trade, you have a higher risk to get exposed to asbestos. Asbestos can cause a deadly and rare disease such as mesothelioma and asbestosis. Increasing public awareness about this dangerous materials must be continued.

One of study in observing this hazardous material is called Apoptosis is observed in mesothelial cells after exposure to crocidolite asbestos by BiruBi KA, Quinlan TR, Fung H, Magae J, Vacek P, Taatjes DJ, and Mossman BT, Department of Pathology, University of Vermont, Burlington.

Here are the excerpt:

  1. Asbestos causes protracted, dose-dependent increases in steady-state mRNA levels of the proto-oncogenes c-fos and c-jun, and AP-1 DNA-binding activity in normal rat pleural mesothelial (RPM) cells
  2. To determine the phenotypic end points of overexpression of these early response genes by asbestos, both cell proliferation and apoptosis were examined in confluent RPM cells exposed to a range of concentrations of crocidolite asbestos for 24 and 48 h.
  3. Quantitation of RPM cells pulsed with 5-bromo-2′-deoxyuridine revealed that asbestos caused dose-dependent decreases in cells undergoing DNA synthesis. Decreases in cell proliferation were accompanied by dose-related increases in apoptosis using terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling, 4′,6-diamidino-2-phenylindole cell staining, and fluorescent-activated cell sorter after incorporation of propidium iodide.
  4. significant dose-related increases in apoptosis were observed in RPM cells exposed to H2O2 (300 microM), and no apoptosis was seen after exposure of cells to high concentrations (10 micrograms/cm2 dish) of glass beads.
  5. See the result. The that asbestos induces apoptosis in mesothelial cells at concentrations eliciting increased expression of the proto-oncogenes c-fos and c-jun.

Another study which called ,  Is lung cancer associated with asbestos exposure when there are no small opacities on the chest radiograph?  by Wilkinson P, Hansell DM, Janssens J, Rubens M, Rudd RM, Taylor AN, McDonald C. – London Chest Hospital, UK. Lancet. 1995 has except like these:

  1. The study was designed to test the hypothesis that the risk of lung cancer from asbestos exposure.
  2. It confined persons with radiographic evidence of pulmonary fibrosis
  3. 271 patiesnts who have occupational and smoking histories were obtained with a confirmed diagnosis of primary lung cancer and 678 referents
  4. Reviewing the histories blind to assess the timing, duration, and probability of exposure to asbestos.
  5. Subjects were classified by the time they had spent in an occupation entailing definite or probable exposure more than 15 years before diagnosis.
  6. Assessing the presence and extent of fibrosis from chest radiographs by three readers and scored for small opacities with the ILO 1989 International Classification of Radiographs of the Pneumoconioses.
  7. The results showed that 93 (34.3%) cases had worked in an occupation with definite or probable asbestos exposure compared with 176 (25.8%) referents (crude odds ratio for lung cancer 1.49, 95% CI 1.09-2.04). It suggest that asbestos is associated with lung cancer even in the absence of radiologically apparent pulmonary fibrosis.


Please read the entire studies if you found either of these studies interesting or helpful,


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